Project 'Molecular simulations of biological processes of protein kinases and peroxiredoxins.'
Project description:
Protein dynamics is a crucial element in protein function, including protein association/dissociation, folding, aggregation, and enzyme catalysis, and many diseases are implicated to develop by disrupting protein dynamics. However, despite the importance of protein dynamics on cellular function and diseases, the fundamental principles of the interplay between protein dynamics and function are less understood. This limits the development of new therapeutic approaches treating diseases, such as, cancer and Alzheimer's disease. In my research lab, we aim to unravel the roles of protein dynamics on function by applying theory and high level computations. Computational approaches are currently the only way yielding detailed information at the atomic level. Our primary targets are protein kinases and perioxiredoxins, as they are implicated in cancer and other diseases, thus, having important biophysical and medicinal interests. We also actively develop new simulation techniques and models to facilitate the study.
The research project that the successful applicant will work on involves the characterization of conformational dynamics of protein kinases and catalytic mechanisms involved in the function of kinase. This work will involve state-of-the-art computer simulation techniques, including but not limited to molecular modeling, molecular dynamics simulations, and quantum mechanics. The project will be carried out by using high performance computers available at HPC2N (http://www.hpc2n.umu.se).
Prerequisites:
The recruitment procedure will follow the Higher Education Ordinance (Hogskoleforordningen Chapters 5 and 7).
Project description:
Protein dynamics is a crucial element in protein function, including protein association/dissociation, folding, aggregation, and enzyme catalysis, and many diseases are implicated to develop by disrupting protein dynamics. However, despite the importance of protein dynamics on cellular function and diseases, the fundamental principles of the interplay between protein dynamics and function are less understood. This limits the development of new therapeutic approaches treating diseases, such as, cancer and Alzheimer's disease. In my research lab, we aim to unravel the roles of protein dynamics on function by applying theory and high level computations. Computational approaches are currently the only way yielding detailed information at the atomic level. Our primary targets are protein kinases and perioxiredoxins, as they are implicated in cancer and other diseases, thus, having important biophysical and medicinal interests. We also actively develop new simulation techniques and models to facilitate the study.
The research project that the successful applicant will work on involves the characterization of conformational dynamics of protein kinases and catalytic mechanisms involved in the function of kinase. This work will involve state-of-the-art computer simulation techniques, including but not limited to molecular modeling, molecular dynamics simulations, and quantum mechanics. The project will be carried out by using high performance computers available at HPC2N (http://www.hpc2n.umu.se).
Prerequisites:
The recruitment procedure will follow the Higher Education Ordinance (Hogskoleforordningen Chapters 5 and 7).
Prerequisites include either
i) 240 ECTS credits (Swe. Hogskolepoang) of higher education studies of which 60 should be on an advanced level (Master level) with focus on chemistry or biophysics or ii) 120 Swedish (old) credits (Swe. Poang; corresponding to 180 ECTS credits) of higher education studies if they were taken before July 1, 2007 or equivalent competence. Advanced course(s) or experiences in computer programming, high-performance computations, and/or NMR or X-ray spectroscopy are a plus, as well as evidence of proficiency in written and oral communication in English.
i) 240 ECTS credits (Swe. Hogskolepoang) of higher education studies of which 60 should be on an advanced level (Master level) with focus on chemistry or biophysics or ii) 120 Swedish (old) credits (Swe. Poang; corresponding to 180 ECTS credits) of higher education studies if they were taken before July 1, 2007 or equivalent competence. Advanced course(s) or experiences in computer programming, high-performance computations, and/or NMR or X-ray spectroscopy are a plus, as well as evidence of proficiency in written and oral communication in English.
Application:
The application should contain a CV, including academic grades and relevant documentation, and a personal letter describing yourself and your reasons for applying to this position. Contact information of at least two referees, familiar with the applicant's qualifications should be provided.
Documents should preferably be sent electronically and should be in MS Word or PDF format. Since we strive for a more equal gender distribution within our department, we especially encourage female applicants.
For more information please contact:
Dr. Kwangho Nam, phone +46 (0)90 786 65 70,
e-mail:Kwangho.Nam@chem.umu.se.
The procedure for recruitment for the position is in accordance with the Higher Education Ordinance (chapter. 12, 2 $) and the decision regarding the position cannot be appealed. Union information is available from SACO, +46-(0)90-786 53 65, SEKO, +46-(0)90-786 52 96 and ST, +46-(0)90-786 54 31.
Your complete application, marked with reference number 313-1188-11, should be sent to jobb%%umu.se(state the reference number as subject) or to the Registrar, Umea University, SE-901 87 Umea, Sweden to arrive January 31, 2012 at the latest.
For more information please contact:
Dr. Kwangho Nam, phone +46 (0)90 786 65 70,
e-mail:Kwangho.Nam@chem.umu.se.
The procedure for recruitment for the position is in accordance with the Higher Education Ordinance (chapter. 12, 2 $) and the decision regarding the position cannot be appealed. Union information is available from SACO, +46-(0)90-786 53 65, SEKO, +46-(0)90-786 52 96 and ST, +46-(0)90-786 54 31.
Your complete application, marked with reference number 313-1188-11, should be sent to jobb%%umu.se(state the reference number as subject) or to the Registrar, Umea University, SE-901 87 Umea, Sweden to arrive January 31, 2012 at the latest.
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