Scientist, Computational Chemistry

Dart NeuroScience LLC (DNS) is a privately held Delaware Limited Liability 
Company with facilities in San Diego CA.  DNS will discover new technologies 
and develop new therapies to help maintain cognitive vitality throughout 
life.  DNSs Scientific Computing Department focuses on (i) development of 
novel bioinformatic tools to facilitate gene discovery, (ii) development of 
novel software tools to facilitate drug discovery, (iii) computational 
chemistry project support, structure-based drug design, combinatorial 
chemistry and statistical modeling, (iii) information systems and 
automation and (iv) general IT infrastructure to support scientific 
research and company administration.

The successful candidate will have broad knowledge and experience applying 
computational chemistry to solve complex scientific problems.  S/he will 
support small-molecule design teams from early screening through lead 
optimization using computational chemistry. The candidate will work with 
the Methods (software), Information Management and Bioinformatics groups 
within the Scientific Computing Department to develop novel tools to 
facilitate small-molecule design.   A solid understanding of 
structure-based and ligand-based drug design is required.  The successful 
candidate will be expected to make individual contributions to drug 
discovery projects and enhance the composition of the DNS compound 
collection through computer-aided design.

Requirements:

- Ph.D. with 3+ years experience (or M.S with 8+) in computer-aided design, 
preferably in the pharmaceutical industry. CNS experience is preferred, 
but not required.

- Extensive experience with structure-based methods such as docking, 
molecular mechanics and homology modeling AND/OR ligand-based methods 
such as pharmacophores and QSAR are preferred.  Knowledge of statistical 
modeling methods and experience using the ChemAxon and OpenEye chemistry 
toolkits and Schrdinger Software would be a plus.  

- Good oral and written communication skills and the ability to communicate 
with medicinal chemistry, informatics, bioinformatics and software 
developers are a must.

- DNS offers competitive salaries and a great benefits package including 
incentive bonuses, healthcare, vision, dental, long-term disability, 
life insurance, flexible spending and a 401(k) retirement savings plan.

Interested individuals should submit a cover letter, curriculum vitae, 
a brief summary of research experience and accomplishments, 
research interests and goals and list of publications using our 
online application: http://jobsco.re/sQD82F.

PDF files are strongly encouraged.

For more information please visit our web site at www.dartneuroscience.com.