PFIZER - Systems Biologist/Toxicologist

We are looking to recruit a Senior Scientist/Principal Scientist for the 
Compound Safety Prediction group (CSP). The CSP group develops and applies 
computational modeling techniques (for physico chemical properties, 
structure activity relationships and biological pathways) in concert with 
mechanism-based screening tools (cell based, in vivo "biosensors" and high 
content biology platforms) to help select the safest chemical substrate. 
Underpinning all of this is a scientific focus on identifying and 
characterizing broad underlying biological mechanisms associated with 
undesired toxicity endpoints. This is an exciting new function for 
Worldwide Research & Development (WRD), with the opportunity to have a 
very positive and impactful contribution to the quality of our portfolio.

This position is for a systems biologist or systems toxicologist to work 
within the Chemical and Biological Mechanisms Group, where the candidate 
will help design and conduct research projects to improve our understanding 
of basic toxicity mechanisms. It will require someone who can put existing 
high-content results and data into biological context in terms of the 
molecular pathways and use this to design experiments that would add 
further understanding or value to the interpretation of the assay results. 
Such results and data may include high content biology/systems biology 
platforms and require knowledge and experience of computational approaches 
for data mining such or pathway mapping.  The position will also be 
expected to make recommendations for follow-on testing to confirm 
hypotheses or design and execute experimental confirmation of the 
mechanisms indicated from their analysis.


WORK EXPERIENCE: 
Experience in molecular biology or toxicology with experience in high 
content data mining / analysis (e.g., ~omics technologies) and multi-
parametric data modeling with a background in one or more of the following: 
 Transcriptomics / Gene Expression data sets
 Proteomics 
 Metabonomics 
 Signal transduction 
 Molecular toxicology


Please apply on-line at our website, www.pfizercareers.com and search for
Job ID 969499.